(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

Base Information

Chemical Name:(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate
CAS No.:122778-42-1
Molecular Formula:C₂₂H₄₄O₃Si
Molecular Weight:384.675
Hs Code.:

Synonyms:(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

Chemical Property:

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Technology Process of (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

There total 3 articles about (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 122778-31-8
(1R,3R,4S)-p-menthan-3-yl (2R)-2-hydroxymethylvalerate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 122778-42-1
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

Guidance literature:: With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 10h; Ambient temperature;

Reference yield:

: 2216-51-5
(-)-menthol

: 122778-42-1
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -40 deg C, 6 h; room temperature, 10 h

2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

3: 87 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; oxalyl dichloride; tetrabutylammonium borohydride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 122778-23-8,122778-24-9
(1R,3R,4S)-p-menthan-3-yl hydrogen propylmalonate

: 122778-42-1
(1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)valerate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

2: 87 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; oxalyl dichloride; tetrabutylammonium borohydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;