(2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester

Base Information

• Chemical Name: (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester
• CAS No.: 19658-95-8
• Molecular Formula: C₃₆H₅₀N₆O₁₁
• Molecular Weight: 742.827
• Mol file: 19658-95-8.mol

Synonyms:

Chemical Property of (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester

There total 7 articles about (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formyl-D-leucine (5338-45-4,6113-61-7,89921-44-8,44978-39-4) → (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester (19658-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC / dimethylformamide

2: N₂H₄*H₂O / methanol / Ambient temperature

3: (i) NaNO₂, aq. HCl, AcOH, (ii) /BRN= 6318073/, AcOEt, DMF

With hydrazine hydrate; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

Reference yield:

L-threonine methyl ester (3373-59-9) → (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester (19658-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC / dimethylformamide

2: aq. HCl / methanol / Ambient temperature

3: (i) NaNO₂, aq. HCl, AcOH, (ii) /BRN= 6318073/, AcOEt, DMF

With hydrogenchloride; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

Reference yield:

methyl (2S) 4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate (55528-35-3) → (2S,3R)-2-{(S)-4-Benzyloxycarbonylamino-2-[(S)-4-benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-3-hydroxy-butyric acid methyl ester (19658-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC / dimethylformamide

2: N₂H₄*H₂O / methanol / Ambient temperature

3: (i) NaNO₂, aq. HCl, AcOH, (ii) /BRN= 6318073/, AcOEt, DMF

With hydrazine hydrate; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

N(γ)-Benzyloxycarbonyl-L-α,γ-diamino-butyryl-L-threonin-methylester

N-formyl-D-leucine

L-threonine methyl ester

methyl (2S) 4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate

Downstream raw materials:

[(S)-3-[(S)-4-Benzyloxycarbonylamino-2-((R)-2-formylamino-4-methyl-pentanoylamino)-butyrylamino]-3-((1S,2R)-1-hydrazinocarbonyl-2-hydroxy-propylcarbamoyl)-propyl]-carbamic acid benzyl ester