3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole

Base Information

• Chemical Name: 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole
• CAS No.: 123532-18-3
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Mol file: 123532-18-3.mol

Synonyms:1-methyl-3-(2'-hydroxyphenyl)pyrazole;Phenol,2-(1-methyl-1H-pyrazol-3-yl);3-(2-hydroxyphenyl)-1-methylpyrazole;3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole;

Chemical Property of 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole

Chemical Property:

• PSA: 37.79000
• LogP: 0.48010

Purity/Quality:

97% ^*data from raw suppliers

2-(1-Methyl-1H-pyrazol-3-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole

There total 19 articles about 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N1-2-(2-hydroxybenzoyl)vinyl-N1-methylhydrazine (123532-14-9) + methylhydrazine (60-34-4) → 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole (123532-18-3)

Guidance literature:

In ethanol; for 48h;

Reference yield: 95.0%

N1-2-(2-hydroxybenzoyl)vinyl-N1-methylhydrazine (123532-14-9) + methylhydrazine (60-34-4) → 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole (123532-18-3) + 1-methyl-5-(2'-hydroxyphenyl)pyrazole (123532-22-9)

Guidance literature:

With pyridine; for 48h;

Reference yield: 90.0%

2-(1H-pyrazol-3-yl)phenol (34810-67-8) + methyl iodide (74-88-4) → 3-(2-hydroxyphenyl)-1-methyl-1H-pyrazole (123532-18-3)

Guidance literature:

2-(1H-pyrazol-3-yl)phenol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/b822144h

upstream raw materials:

1-benzopyran-4(4H)-one

methylhydrazine

thiochromone

N₁-2-(2-hydroxybenzoyl)vinyl-N₁-methylhydrazine

Downstream raw materials:

1-methyl-3-(2'-methoxyphenyl)pyrazole

(4-(2-(1-methyl-1H-pyrazol-3-yl))phenyloxy)-3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphtalene

C₁₂H₁₅N₃O₃S