ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxyla te

Base Information

• Chemical Name: ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxyla te
• CAS No.: 123542-47-2
• Molecular Formula: C15H13N3O3S
• Molecular Weight: 315.353
• Mol file: 123542-47-2.mol

Synonyms:5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester;ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate;

Chemical Property of ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxyla te

Chemical Property:

• PSA: 115.45000
• LogP: 2.78730

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxyla te

There total 7 articles about ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxyla te which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 5-cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (89516-24-5) → ethyl 5-amino-3,4-dihydro-4-oxo-3-phenylthieno<3,4-d>pyridazine-1-carboxylate (123542-47-2)

Guidance literature:

With piperidine; sulfur; In N,N-dimethyl-formamide; for 0.0333333h; Heating; microwave irradiation;

DOI:10.1080/10426500500536457

Reference yield: 64.0%

ethanol (64-17-5) + 5-cyano-4-methyl-1-phenyl-1,6-dihydro-6-oxopyridazine-3-carboxylic acid (115592-38-6) → ethyl 5-amino-3,4-dihydro-4-oxo-3-phenylthieno<3,4-d>pyridazine-1-carboxylate (123542-47-2)

Guidance literature:

With piperidine; sulfur; for 4h; Heating;

Reference yield:

ethyl (Z)-3-oxo-2-(2-phenylhydrazono)butanoate (60083-15-0) → ethyl 5-amino-3,4-dihydro-4-oxo-3-phenylthieno<3,4-d>pyridazine-1-carboxylate (123542-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / ammonium acetate; acetic acid / 0.02 h / Heating; microwave irradiation

2: 80 percent / sulfur; piperidine / dimethylformamide / 0.03 h / Heating; microwave irradiation

With piperidine; ammonium acetate; sulfur; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1080/10426500500536457

upstream raw materials:

ethanol

5-cyano-4-methyl-1-phenyl-1,6-dihydro-6-oxopyridazine-3-carboxylic acid

ethyl 5-cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate

ethyl (Z)-3-oxo-2-(2-phenylhydrazono)butanoate

Downstream raw materials:

diethyl 5-amino-3,4-dihydro-4-oxo-3-phenylphthalazine-1,6-dicarboxylate

1-ethyl-6,7-dimethyl-5-amino-4-oxo-3-phenyl-3,4-dihydrophthalazine-1,6,7-tricarboxylate

5-acetylamino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester

ethyl 5-amino-6-cyano-3,4-dihydro-4-oxo-3-phenylphthalazine-1-carboxylate