4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester
• CAS No.: 1053743-24-0
• Molecular Formula: C₄₅H₄₆Cl₂N₉O₁₄PS
• Molecular Weight: 1070.86

Synonyms:

Chemical Property of 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

There total 6 articles about 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C43H44Cl2N8O14PS(1-) + cyanomethyl bromide (590-17-0) → 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester (1053743-24-0)

Guidance literature:

C₄₃H₄₄Cl₂N₈O₁₄PS^(1-); With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.0833333h;

cyanomethyl bromide; With N,N-dimethyl-aniline; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/S0040-4039(03)00322-8

Reference yield:

C37H35N3O9P(1-) → 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester (1053743-24-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: (PhO)2POCl; C₅H₅N / 20 °C

2.1: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

3.1: C₅H₅N / 20 °C

4.1: DBU / CH₂Cl₂ / 0.5 h / 20 °C

5.1: CF₃CO₂H / CH₂Cl₂ / 0.08 h / 20 °C

5.2: PhNMe₂ / CH₂Cl₂ / 15 h / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; 1,8-diazabicyclo[5.4.0]undec-7-ene; chlorophosphoric acid diphenyl ester; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(03)00322-8

Reference yield:

2'-deoxy-6-O-(2,5-dichlorophenyl)-2-N-isobutyryl-3'-O-levulinylguanosine (199436-66-3) → 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester (1053743-24-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: (PhO)2POCl; C₅H₅N / 20 °C

2.1: Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 20 °C

3.1: C₅H₅N / 20 °C

4.1: DBU / CH₂Cl₂ / 0.5 h / 20 °C

5.1: CF₃CO₂H / CH₂Cl₂ / 0.08 h / 20 °C

5.2: PhNMe₂ / CH₂Cl₂ / 15 h / 20 °C

With pyridine; dichloro-acetic acid; pyrrole; 1,8-diazabicyclo[5.4.0]undec-7-ene; chlorophosphoric acid diphenyl ester; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(03)00322-8

upstream raw materials:

cyanomethyl bromide

2'-deoxy-6-O-(2,5-dichlorophenyl)-2-N-isobutyryl-3'-O-levulinylguanosine

4-oxo-pentanoic acid 2-[[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

C₆₅H₆₄Cl₂N₉O₁₅PS

Downstream raw materials:

deoxycytidylyl-(3',5')-guanosine sodium salt

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1053743-24-0 4-oxo-pentanoic acid 2-{[2-acetoxymethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-cyanomethylsulfanyl-phosphoryloxymethyl}-5-[6-(2,5-dichloro-phenoxy)-2-isobutyrylamino-purin-9-yl]-tetrahydro-furan-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send