Ethyl 3-(1-benzylpiperidin-4-yl)propanoate

Base Information

Chemical Name:Ethyl 3-(1-benzylpiperidin-4-yl)propanoate
CAS No.:124438-69-3
Molecular Formula:C17H25NO2
Molecular Weight:275.391
Hs Code.:
DSSTox Substance ID:DTXSID10566622
Wikidata:Q82452315
Mol file:124438-69-3.mol

Synonyms:Ethyl 3-(1-benzylpiperidin-4-yl)propanoate;124438-69-3;4-Piperidinepropanoic acid, 1-(phenylmethyl)-, ethyl ester;SCHEMBL9218378;DTXSID10566622;LUSHYPLDRVACQI-UHFFFAOYSA-N;ethyl 3-(1-benzylpiperidin-4-yl)propionate;ethyl 1-(phenylmethyl)-4-piperidinepropanoate

Suppliers and Price of Ethyl 3-(1-benzylpiperidin-4-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ethyl 3-(1-benzylpiperidin-4-yl)propanoate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:275.188529040
Heavy Atom Count:20
Complexity:279

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CCC1CCN(CC1)CC2=CC=CC=C2

Technology Process of Ethyl 3-(1-benzylpiperidin-4-yl)propanoate

There total 17 articles about Ethyl 3-(1-benzylpiperidin-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4-(2-ethoxycarbonylethyl)piperidine acetate

: 100-39-0
benzyl bromide

: 124438-69-3
3-(1-Benzyl-piperidin-4-yl)-propionic acid,ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 28 ℃; Inert atmosphere;
DOI:10.1002/ejoc.202000695

Reference yield: 37.0%

: 71879-55-5
ethyl 3-(piperid-4-yl)propionate

: 100-39-0
benzyl bromide

: 124438-69-3
3-(1-Benzyl-piperidin-4-yl)-propionic acid,ethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

: 2564-06-9
N-benzyl-2-chloroacetamide

: 124438-69-3
3-(1-Benzyl-piperidin-4-yl)-propionic acid,ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 12.88 g / dioxane; H₂O / 10 h / Heating

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 54 percent / tetrahydrofuran / 0.5 h / Heating

3.1: 94 percent / H₂ / Pd/C / ethyl acetate / 3 h / 20 °C

4.1: Na; liq. NH₃ / 2 h / -78 - -30 °C

5.1: 433 mg / LiAlH₄ / tetrahydrofuran / 2 h / Heating

6.1: Jones reagent / acetone / 0.17 h / cooling

7.1: 184 mg / TFA / 5 h / 20 °C

With lithium aluminium tetrahydride; jones reagent; ammonia; hydrogen; sodium; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetone;
DOI:10.1002/jccs.200200156