Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene] -2'-O-[(1,1-dimethylethyl)dimethylsilyl]-

Base Information

• Chemical Name: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene] -2'-O-[(1,1-dimethylethyl)dimethylsilyl]-
• CAS No.: 124492-53-1
• Molecular Formula: C40H50N6O6Si
• Molecular Weight: 738.959
• Mol file: 124492-53-1.mol

Synonyms:

Chemical Property of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene] -2'-O-[(1,1-dimethylethyl)dimethylsilyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene] -2'-O-[(1,1-dimethylethyl)dimethylsilyl]-

There total 4 articles about Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene] -2'-O-[(1,1-dimethylethyl)dimethylsilyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethyleneadenosine (73793-98-3) + tert-butyldimethylsilyl chloride (18162-48-6) → N6-(N,N'-Dimethylaminomethylene)-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)adenosine (124492-53-1)

Guidance literature:

With pyridine; silver nitrate; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1055/s-1989-27258

Reference yield:

N6-(N,N'-Dimethylaminomethylene)adenosine (17331-15-6) → N6-(N,N'-Dimethylaminomethylene)-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)adenosine (124492-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / dimethylformamide; pyridine / 10 h / Ambient temperature

2: 80 percent / AgNO₃, pyridine / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; silver nitrate; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1055/s-1989-27258

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N6-(N,N'-Dimethylaminomethylene)-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)adenosine (124492-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / dimethylformamide; pyridine / 10 h / Ambient temperature

2: 80 percent / AgNO₃, pyridine / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; silver nitrate; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1055/s-1989-27258

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine

tert-butyldimethylsilyl chloride

4,4'-dimethoxytrityl chloride

N,N-dimethyl-formamide

Downstream raw materials:

5'-O-(4,4'-Dimethoxytrityl)-2'-O-tert-butyldimethylsilyl-β-D-xylofuranosyl-N⁶-(N,N'-dimethylaminomethylene)adenine

C₄₀H₅₁N₆O₈PSi*C₆H₁₅N

N'-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea