73793-98-3Relevant articles and documents
High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis
Zhang, Xiaohu,Abad, Jose-Luis,Huang, Qingtao,Zeng, Fan,Gaffney, Barbara L.,Jones, Roger A.
, p. 7135 - 7138 (1997)
We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.
Synthesis of 9-β-D-(Xylofuranosyl)adenine from Adenosine
Xi, Cheng,Jun-Dong, Zhang,Li-He, Zhang
, p. 383 - 384 (2007/10/02)
Protected adenosine 3 was oxidized using Moffatt reagent to give the 3'-ketoadenosine 4 in 60percent yield.Stereospecific reduction of 4 with sodium borohydride in the presence of triethylamine at -18 deg C followed by deprotection effects the inversion o