C₂₂H₂₃FN₂O₃S₂

Base Information

• Chemical Name: C₂₂H₂₃FN₂O₃S₂
• CAS No.: 1259394-61-0
• Molecular Formula: C₂₂H₂₃FN₂O₃S₂
• Molecular Weight: 446.567
• Mol file: 1259394-61-0.mol

Synonyms:

Chemical Property of C₂₂H₂₃FN₂O₃S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₃FN₂O₃S₂

There total 5 articles about C₂₂H₂₃FN₂O₃S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1S)-amino(4-tolyl)oxido-λ4-sulfanylidene]tosylamide (816444-61-8) + 1-ethyl-4-fluorobenzene (459-47-2) + ethylbenzene (100-41-4,27536-89-6) → (1R)-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-1-aminoethylbenzene (908013-49-0) + C22H23FN2O3S2 (1259394-61-0)

Guidance literature:

With Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; In methanol; 1,1,2,2-tetrachloroethane; at -35 ℃; for 72h; Inert atmosphere; Molecular sieve;

DOI:10.1039/c0dt00283f

Reference yield:

(1R)-[N-(p-toluenesulfonyl)-p-toluenesulfonimidoyl]-1-aminoethylbenzene → C22H23FN2O3S2 (1259394-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 40 h / 35 °C

2: Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene / methanol; 1,1,2,2-tetrachloroethane / 72 h / -35 °C / Inert atmosphere; Molecular sieve

With Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; trifluoroacetic acid; In methanol; 1,1,2,2-tetrachloroethane;

DOI:10.1039/c0dt00283f

Reference yield:

chloroamine-T (127-65-1) → C22H23FN2O3S2 (1259394-61-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / toluene / 14 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.5 h / 80 °C

2.1: sodium hydrogencarbonate / dichloromethane; water / 0 - 20 °C

3.1: trifluoroacetic acid / 40 h / 35 °C

4.1: Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene / methanol; 1,1,2,2-tetrachloroethane / 72 h / -35 °C / Inert atmosphere; Molecular sieve

With thionyl chloride; Rh₂{(S)-nta}4; bis(tertbutylcarbonyloxy)iodobenzene; sodium hydrogencarbonate; trifluoroacetic acid; In methanol; dichloromethane; water; toluene; 1,1,2,2-tetrachloroethane;

DOI:10.1039/c0dt00283f

upstream raw materials:

N-[(1S)-amino(4-tolyl)oxido-λ⁴-sulfanylidene]tosylamide

1-ethyl-4-fluorobenzene

ethylbenzene

N-(4-methylbenzenesulfonyl) 4-methylphenyl sulfonimidoyl chloride