2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanol

Base Information

• Chemical Name: 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanol
• CAS No.: 127264-09-9
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID70599517
• Wikidata: Q82495412
• Mol file: 127264-09-9.mol

Synonyms:127264-09-9;2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethanol;2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-ol;2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHANOL;2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-ol;SCHEMBL3777135;DTXSID70599517;ZWKJGSFAORXDED-UHFFFAOYSA-N;MFCD09926232;AKOS012084726;CCG-321328;NS-01563;1,4-Benzodioxin-6-ethanol, 2,3-dihydro-;DB-291604;CS-0308153;EN300-109852;G23567;2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-ethanol;J-505459;Z1020779878

Chemical Property of 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanol

Chemical Property:

• PSA: 38.69000
• LogP: 0.99260
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C(O1)C=CC(=C2)CCO

Technology Process of 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanol

There total 4 articles about 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dihydro-1,4-benzodioxin-6-ylacetic acid (17253-11-1) → 1′-(dihydro-3,4-benzodioxinyl)ethan-2′-ol (127264-09-9)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 92.0%

→ 1′-(dihydro-3,4-benzodioxinyl)ethan-2′-ol (127264-09-9)

Guidance literature:

Reference yield: 85.4%

6-vinyl-2,3-dihydrobenzo[b][1,4]dioxine (67200-27-5) → 1′-(dihydro-3,4-benzodioxinyl)ethan-2′-ol (127264-09-9)

Guidance literature:

6-vinyl-2,3-dihydrobenzo[b][1,4]dioxine; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 20 ℃; for 18h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 1h;

upstream raw materials:

6-vinyl-2,3-dihydrobenzo[b][1,4]dioxine

2,3-dihydro-1,4-benzodioxin-6-ylacetic acid

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

Downstream raw materials:

2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl 4-methylbenzenesulfonate

4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

4-(2-bromo-5-ethoxybenzyl)-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-piperidine

4-(2-bromo-5-methoxybenzyl)-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-piperidine