67200-27-5

Upstream product

• 7338-03-6 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-ol 
• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 2768-02-7 (vinyl)trimethoxylsilane 
• 52287-51-1 6-bromo-1,4-benzodioxane 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 2879-20-1 1,4-benzodioxan-6-yl methyl ketone 

Downstream Products

• 127264-09-9 1′-(dihydro-3,4-benzodioxinyl)ethan-2′-ol 
• 4442-54-0 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 
• 910241-05-3 tert-butyl 2-amino-4-((E)-2-(2,3-dihydrobenzo[1,4]dioxin-6-yl)ethyl)benzoate 
• 910241-00-8 tert-butyl 4-((E)-2-(2,3-dihydrobenzo[1,4]dioxin-6-yl)vinyl)-2-nitrobenzoate 

Relevant academic research and scientific papers

6-CYCLOPROPYL- AND 6-(1-METHYLCYCLOPROPYL)-1,4-BENZODIOXANES: SYNTHESIS AND NITRATION. REARRANGEMENT OF NITRO SUBSTITUTED 6-CYCLOPROPYL-1,4-BENZODIOXANES USING CONCENTRATED SULFURIC ACID

6-Cyclopropyl- and 6-(1-methylcyclopropyl)-1,4-benzodioxanes have been synthesized as the first cyclopropyl-1,4-benzodioxanes.It was shown that nitration of these compounds occurs with retention of the three carbon ring.In contrast to simple ethers of cyclopropylphenols, nitration leads only to 7-nitro-6-cyclopropyl- and 7-nitro-6-(1-methylcyclopropyl)-1,4-benzodioxanes, respectively.Nitration of 7-nitro-6-cyclopropyl-1,4-benzodioxane occurs regioselectively to give exclusively the 7,8-dinitro product.The structure of the nitration products was confirmed by their rearrangement to the corresponding nitrosopropionyl-1,4-benzodioxanes.

Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane

We herein disclose the first Ni-catalyzed Hiyama coupling of aryl halides with vinylsilanes. This protocol uses cheap, nontoxic, and stable vinyltrimethoxysilane as the vinyl donor, proceeds under mild and ligand-free conditions, furnishing a diverse variety of styrene derivatives in high yields with excellent functional group compatibility.

NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF

The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

COMPOUNDS AS MODULATORS OF TLR2 SIGNALING

The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

NOVEL INHIBITORS

The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

5-Quinoline derivatives having an anti-bacterial activity

The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.

Pinacolboratamethyl-enetriphenylphosphonium iodide, a new methylene transfer reagent

The title compound is easily prepared and reacts with various aldehydes and ketone. The reagent is compatible with free hydroxy groups. Yields with various aldehydes and ketones are in 50- > 99% range. Both aliphatic, aromatic and unsaturated carbonyls react.