67200-27-5Relevant articles and documents
6-CYCLOPROPYL- AND 6-(1-METHYLCYCLOPROPYL)-1,4-BENZODIOXANES: SYNTHESIS AND NITRATION. REARRANGEMENT OF NITRO SUBSTITUTED 6-CYCLOPROPYL-1,4-BENZODIOXANES USING CONCENTRATED SULFURIC ACID
Mochalov, S. S.,Kosynkin, D. V.,Yudin, I. D.,Zavodskikh, K. A.,Shabarov, Yu. S.,Zefirov, N. S.
, p. 413 - 419 (1994)
6-Cyclopropyl- and 6-(1-methylcyclopropyl)-1,4-benzodioxanes have been synthesized as the first cyclopropyl-1,4-benzodioxanes.It was shown that nitration of these compounds occurs with retention of the three carbon ring.In contrast to simple ethers of cyclopropylphenols, nitration leads only to 7-nitro-6-cyclopropyl- and 7-nitro-6-(1-methylcyclopropyl)-1,4-benzodioxanes, respectively.Nitration of 7-nitro-6-cyclopropyl-1,4-benzodioxane occurs regioselectively to give exclusively the 7,8-dinitro product.The structure of the nitration products was confirmed by their rearrangement to the corresponding nitrosopropionyl-1,4-benzodioxanes.
NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF
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Paragraph 00361, (2020/12/01)
The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.
NOVEL INHIBITORS
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Page/Page column 110, (2011/05/03)
The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
