N-<(α-phenylethylidene)amino>ephedrine

Base Information

• Chemical Name: N-<(α-phenylethylidene)amino>ephedrine
• CAS No.: 80693-34-1
• Molecular Formula: C₁₈H₂₂N₂O
• Molecular Weight: 282.385
• Mol file: 80693-34-1.mol

Synonyms:

Chemical Property of N-<(α-phenylethylidene)amino>ephedrine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(α-phenylethylidene)amino>ephedrine

There total 1 articles about N-<(α-phenylethylidene)amino>ephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(1R,2S)-N-amino-2-methylamino-1-phenyl-1-propanol (67462-20-8) + acetophenone (98-86-2) → N-<(α-phenylethylidene)amino>ephedrine (80693-33-0,80693-34-1)

Guidance literature:

In benzene; for 36h; Ambient temperature;

DOI:10.1248/cpb.29.3387

Reference yield: 70.0%

N-<(α-phenylethylidene)amino>ephedrine (80693-33-0,80693-34-1) → N-(α-phenylethylamino)ephedrine (72519-00-7,80735-89-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3.25h; Heating;

DOI:10.1248/cpb.29.3387

Reference yield:

N-<(α-phenylethylidene)amino>ephedrine (80693-33-0,80693-34-1) → ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / lithium aluminium hydride / diethyl ether / 3.25 h / Heating

2: conc. HCl, hydrogen / 10percent Pd-carbon / ethanol / 12 h / 45 °C / 4045.3 Torr

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1248/cpb.29.3387

upstream raw materials:

(1R,2S)-N-amino-2-methylamino-1-phenyl-1-propanol

acetophenone

Downstream raw materials:

N-(α-phenylethylamino)ephedrine

(S)-1-phenyl-ethylamine

ephedrine