tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester

Base Information

• Chemical Name: tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester
• CAS No.: 97640-06-7
• Molecular Formula: C₆₅H₁₀₄N₁₀O₁₆
• Molecular Weight: 1281.6

Synonyms:

Chemical Property of tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester

There total 4 articles about tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-leucine tert-butyl ester (21691-53-2) → tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-Nε-tert-butyloxycarbonyllysyl-Nε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester (97640-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 1-hydroxybenzotriazole, dicyclohexylacarbodiimide / CHCl₃; dimethylformamide / 1 h / -15 °C

2: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. chloroform, DMF, -15 deg C, 1 h

3: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. DMF

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide;

DOI:10.1135/cccc19852084

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-Nε-tert-butyloxycarbonyllysyl-Nε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester (97640-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 1-hydroxybenzotriazole, dicyclohexylacarbodiimide / CHCl₃; dimethylformamide / 1 h / -15 °C

2: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. chloroform, DMF, -15 deg C, 1 h

3: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. DMF

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide;

DOI:10.1135/cccc19852084

Reference yield:

Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester (97640-02-3) → tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-Nε-tert-butyloxycarbonyllysyl-Nε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester (97640-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. chloroform, DMF, -15 deg C, 1 h

2: 1. H₂; 2. 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1. Pd black / 1. methanol, 6 h; 2. DMF

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium;

DOI:10.1135/cccc19852084

upstream raw materials:

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

N^α-benzyloxycarbonyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester

L-leucine tert-butyl ester

Z-Lys(Boc)-OH

Downstream raw materials:

tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-lysyl-lysyl-leucine

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