(R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE

Base Information

• Chemical Name: (R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE
• CAS No.: 129025-85-0
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Mol file: 129025-85-0.mol

Synonyms:(R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE;ethyl (R)-3-methyl-2-hydroxybutanoate;R-Ethyl 3-Methyl-2-Hydroxybutanoate;(R)-ETHYL 2-HYDROXY-3-METHYLBUTANOATE;ethyl 3-methyl-2-oxobutyrate;Ethyl 2-Hydroxy-3-Methylbutanoate;(R)-2-Hydroxy-3-methyl-butyric acid ethyl ester;Ethyl (R)-2-Hydroxy-3-Methylbutanoate;(R)-ETHYL 3-METHYL-2 -HYDROXYBUTANOATE;D-2-Hydroxy-isovaleriansaeure-ethylester;(R)-Ethyl2-hydroxy-3-methylbutanoate;(R)-ETHYL3-METHYL-2-HYDROXYBUTANOATE;(R)-ethyl 2-hydroxy-3-methylbutyrate;

Chemical Property of (R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE

Chemical Property:

• Boiling Point: 72 - 73 °C (15 mmHg)
• PKA: 13.07±0.20(Predicted)
• PSA: 46.53000
• Density: 1.002±0.06 g/cm3(Predicted)
• LogP: 0.56640
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE

There total 1 articles about (R)-ETHYL 3-METHYL-2-HYDROXYBUTANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + ethyl 3-methyl-2-oxobutanoate (20201-24-5) → methyl 2-hydroxy-3-methylbutanoate (17417-00-4) + ethyl (2S)-2-hydroxy-3-methylbutanoate (63674-18-0) + ethyl (R)-2-hydroxy-3-methylbutyrate (129025-85-0)

Guidance literature:

With hydrogen; chiral Ru complex; at 20 ℃; for 100h; under 25857.4 Torr; Title compound not separated from byproducts;

DOI:10.1021/ja0602694

Reference yield: 63.0%

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) + ethyl (R)-2-hydroxy-3-methylbutyrate (129025-85-0) → (R)-2-(4-Methoxy-benzyloxy)-3-methyl-butyric acid ethyl ester (189164-68-9)

Guidance literature:

With trifluorormethanesulfonic acid; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(97)00228-7

Reference yield: 51.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + ethyl (R)-2-hydroxy-3-methylbutyrate (129025-85-0) → (S)-ethyl 2-(4-formylphenoxy)-3-methylbutanoate (1041612-09-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

methanol

ethyl 3-methyl-2-oxobutanoate

Downstream raw materials:

(R)-2-(4-Methoxy-benzyloxy)-3-methyl-butyric acid ethyl ester

(2R,3R,4R)-1,2-epoxy-3-methoxy-4-(4-methoxybenzyl)oxy-5-methylhexane

(2R,3S,6R,7S,8R)-6-hydroxy-1,2-isopropylidenedioxy-7-methoxy-8-(4-methoxybenzyl)oxy-3,9-dimethyl-4-(1,3-dithian-2-yl)-decane

(2R,3S,6R,7S,8R)-6-(t-butyldimethylsiloxy)-1,2-epoxy-7-methoxy-8-(4-methoxybenzyl)oxy-3,9-dimethyl-4-(1,3-dithian-2-yl)-decane

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