Tosylate of Hexaethylene glycol monobenzyl ether

Base Information

• Chemical Name: Tosylate of Hexaethylene glycol monobenzyl ether
• CAS No.: 129086-11-9
• Molecular Formula: C26H38O9S
• Molecular Weight: 526.648
• Mol file: 129086-11-9.mol

Synonyms:Tosylate of Hexaethylene glycol monobenzyl ether;Toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester;

Chemical Property of Tosylate of Hexaethylene glycol monobenzyl ether

Chemical Property:

• PSA: 107.13000
• LogP: 4.08090

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tosylate of Hexaethylene glycol monobenzyl ether

There total 8 articles about Tosylate of Hexaethylene glycol monobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol (24342-68-5,1201808-31-2) + p-toluenesulfonyl chloride (98-59-9) → 19-Phenyl-3,6,9, 12,15,18-hexaoxanonadec-1-yl 4-methylbenzenesulfonate (129086-11-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo035042v

Reference yield: 83.0%

toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester (42749-28-0) + benzyl bromide (100-39-0) → 19-Phenyl-3,6,9, 12,15,18-hexaoxanonadec-1-yl 4-methylbenzenesulfonate (129086-11-9)

Guidance literature:

With pyridine; In tetrahydrofuran; for 16h; Heating;

DOI:10.1021/jo035042v

Reference yield:

pentaethylene glycol (2615-15-8) → 19-Phenyl-3,6,9, 12,15,18-hexaoxanonadec-1-yl 4-methylbenzenesulfonate (129086-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Ag₂O; KI / CH₂Cl₂

2: 83 percent / pyridine / tetrahydrofuran / 16 h / Heating

With pyridine; potassium iodide; silver(l) oxide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo035042v

upstream raw materials:

1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol

p-toluenesulfonyl chloride

toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester

benzyl bromide

Downstream raw materials:

{2-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-benzene

2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine

(2-{2-[2-(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene

(2-{2-[2-(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene