Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester

Base Information

• Chemical Name: Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester
• CAS No.: 102065-49-6
• Molecular Formula: C₁₀H₉N₆O₂P
• Molecular Weight: 276.194
• Mol file: 102065-49-6.mol

Synonyms:

Chemical Property of Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester

There total 2 articles about Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-Triazole (288-88-0) + O-phenyl phosphorodichloridate (770-12-7) → Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester (102065-49-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.75h;

DOI:10.1021/jm00093a003

Reference yield:

1,2,4-Triazole (288-88-0) + chlorophosphoric acid diphenyl ester (2524-64-3) → Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester (102065-49-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1039/d0nj04194g

Reference yield:

Bis-[1,2,4]triazol-1-yl-phosphinic acid phenyl ester (102065-49-6) → Phosphoric acid (2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl ester phenyl ester; compound with ammonia (142068-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-methylimidazole, 2.) H₂O, Et₃N / 1.) THF, 2 h, 2.) 2 h

2: 30percent aq. NH₄OH

With 1-methyl-1H-imidazole; ammonium hydroxide; water; triethylamine;

DOI:10.1021/jm00093a003

upstream raw materials:

1,2,4-Triazole

O-phenyl phosphorodichloridate

chlorophosphoric acid diphenyl ester

Downstream raw materials:

Phosphoric acid (2S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester phenyl ester; compound with ammonia

Phosphoric acid (2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl ester phenyl ester; compound with ammonia