Benzamide, N,N-dicyclohexyl-4-methoxy-

Base Information

• Chemical Name: Benzamide, N,N-dicyclohexyl-4-methoxy-
• CAS No.: 129721-53-5
• Molecular Formula: C20H29NO2
• Molecular Weight: 315.45000
• Mol file: 129721-53-5.mol

Synonyms:N,N-dicyclohexyl-p-anisamide;

Chemical Property of Benzamide, N,N-dicyclohexyl-4-methoxy-

Chemical Property:

• PSA: 29.54000
• LogP: 4.80280

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dicyclohexyl-4-methoxybenzamide, 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, N,N-dicyclohexyl-4-methoxy-

There total 3 articles about Benzamide, N,N-dicyclohexyl-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxy-benzoyl chloride (100-07-2) + N-cyclohexyl-cyclohexanamine (101-83-7) → N,N-dicyclohexyl-4-methoxybenzamide (129721-53-5)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1039/b514558a

Reference yield: 59.0%

carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) + N-cyclohexyl-cyclohexanamine (101-83-7) → N,N-dicyclohexyl-4-methoxybenzamide (129721-53-5)

Guidance literature:

With triethylamine; triphenylphosphine; In acetonitrile; at 125 ℃; for 1.5h; under 7500.75 Torr; Reagent/catalyst; Microwave irradiation; Inert atmosphere;

DOI:10.1021/op5003374

Reference yield: 22.0%

carbon monoxide (201230-82-2) + 4-methoxyphenylboronic acid (5720-07-0) + N-cyclohexyl-cyclohexanamine (101-83-7) → N,N-dicyclohexyl-4-methoxybenzamide (129721-53-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; oxygen; copper; In dimethyl sulfoxide; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.orglett.6b02913

upstream raw materials:

4-methoxy-benzoyl chloride

N-cyclohexyl-cyclohexanamine

carbon monoxide

para-iodoanisole

Downstream raw materials:

N,N-dicyclohexyl-2-formyl-p-anisamide

N,N-dicyclohexyl-2-formyl-6-[(S)-p-toluenesulfinyl]-p-anisamide

Refernces

• 1、 Calcio Gaudino, Emanuela,Carnaroglio, Diego,Martina, Katia,Palmisano, Giovanni,Penoni, Andrea,Cravotto, Giancarlo. "Highly efficient microwave-assisted CO aminocarbonylation with a recyclable Pd(II)/TPP-β-cyclodextrin cross-linked catalyst". supporting information. p. 499 - 505. Retrieved 2015/04/27.