rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

Base Information

Chemical Name:rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester
CAS No.:1229705-02-5
Molecular Formula:C₃₀H₂₈Cl₂F₂N₄O₃
Molecular Weight:601.48
Hs Code.:

rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

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Chemical Property of rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

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Technology Process of rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

There total 9 articles about rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229704-88-4
(2R,3S,4R,5S)-4-(4-chloro-2-fluorophenyl)-3-(3-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid (5-iodopyridin-2-yl)amide

: 3375-31-3
palladium diacetate

: 1229705-02-5
rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

Guidance literature:: With carbon monoxide; potassium carbonate; In water; N,N-dimethyl-formamide; at 70 ℃; for 3h; under 2068.65 Torr;
DOI:10.1021/jm400487c

Reference yield:

: 1219086-87-9
(Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile

: 1229705-02-5
rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; silver fluoride / dichloromethane / 18 h / 20 °C

2.1: dichloromethane / 18 h / 20 °C

3.1: methanol / 30 °C / 75007.5 Torr

4.1: N-ethyl-N,N-diisopropylamine; diphenylphosphinic chloride / dichloromethane / 0.5 h / 20 °C

4.2: 18 h / 20 °C

5.1: potassium carbonate; carbon monoxide / water; N,N-dimethyl-formamide / 3 h / 70 °C / 2068.65 Torr

With carbon monoxide; diphenylphosphinic chloride; silver fluoride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400487c

Reference yield:

: 1219086-34-6
2-[(E)-(3,3-dimethylbutylidene)amino]acetic acid tert-butyl ester

: 1229705-02-5
rac-6-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; silver fluoride / dichloromethane / 18 h / 20 °C

2.1: dichloromethane / 18 h / 20 °C

3.1: methanol / 30 °C / 75007.5 Torr

4.1: N-ethyl-N,N-diisopropylamine; diphenylphosphinic chloride / dichloromethane / 0.5 h / 20 °C

4.2: 18 h / 20 °C

5.1: potassium carbonate; carbon monoxide / water; N,N-dimethyl-formamide / 3 h / 70 °C / 2068.65 Torr

With carbon monoxide; diphenylphosphinic chloride; silver fluoride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400487c