Technology Process of C26H24F3NO5
There total 12 articles about C26H24F3NO5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
tetrahydrofuran;
at 18 ℃;
for 1.5h;
Inert atmosphere;
(±)-haemultine;
With
dmap;
In
tetrahydrofuran; toluene;
at 90 - 105 ℃;
for 5h;
Inert atmosphere;
DOI:10.1071/CH12473
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate
2.1: sodium hydride / N,N-dimethyl-formamide
3.1: palladium diacetate; N,N'-bis(benzyliden)ethylendiamine / benzene / 7 h / 80 °C
4.1: ozone / dichloromethane; methanol / 0.03 h / -78 °C
4.2: 0.5 h
5.1: thiophenol; caesium carbonate / acetonitrile / 0 - 18 °C / Inert atmosphere
5.2: 1 h / 0 - 18 °C
6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 18 h / 60 °C
7.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1.5 h / 18 °C / Inert atmosphere
7.2: 5 h / 90 - 105 °C / Inert atmosphere
With
N,N'-bis(benzyliden)ethylendiamine; 2,4,6-trichlorobenzoyl chloride; palladium diacetate; sodium hydride; sodium carbonate; caesium carbonate; ozone; thiophenol; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; benzene;
1.1: |Suzuki-Miyaura Coupling / 6.1: |Pictet-Spengler Synthesis;
DOI:10.1071/CH12473
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide
2.1: palladium diacetate; N,N'-bis(benzyliden)ethylendiamine / benzene / 7 h / 80 °C
3.1: ozone / dichloromethane; methanol / 0.03 h / -78 °C
3.2: 0.5 h
4.1: thiophenol; caesium carbonate / acetonitrile / 0 - 18 °C / Inert atmosphere
4.2: 1 h / 0 - 18 °C
5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 18 h / 60 °C
6.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1.5 h / 18 °C / Inert atmosphere
6.2: 5 h / 90 - 105 °C / Inert atmosphere
With
N,N'-bis(benzyliden)ethylendiamine; 2,4,6-trichlorobenzoyl chloride; palladium diacetate; sodium hydride; caesium carbonate; ozone; thiophenol; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; benzene;
5.1: |Pictet-Spengler Synthesis;
DOI:10.1071/CH12473
