(S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione

Base Information

• Chemical Name: (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione
• CAS No.: 532413-13-1
• Molecular Formula: C₃₀H₄₂N₂O₅Si
• Molecular Weight: 538.759
• Mol file: 532413-13-1.mol

Synonyms:

Chemical Property of (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione

There total 5 articles about (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione (532413-13-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / NaH / dimethylformamide

2: LDA; SnCl₄ / diethyl ether / 4 h / -78 °C

3: LDA / tetrahydrofuran / 2 h / -20 °C

4: imidazole / dimethylformamide

With 1H-imidazole; tin(IV) chloride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02701-6

Reference yield:

1,3-dibenzyldihydropyrimidine-2,4(1H,3H)-dione (75500-04-8) → (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione (532413-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA; SnCl₄ / diethyl ether / 4 h / -78 °C

2: LDA / tetrahydrofuran / 2 h / -20 °C

3: imidazole / dimethylformamide

With 1H-imidazole; tin(IV) chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02701-6

Reference yield:

(R)-1,3-Dibenzyl-5-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-dihydro-pyrimidine-2,4-dione (532413-11-9) → (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione (532413-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 2 h / -20 °C

2: imidazole / dimethylformamide

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)02701-6

upstream raw materials:

tert-butyldimethylsilyl chloride

(S)-1,3-Dibenzyl-5-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-dihydro-pyrimidine-2,4-dione

benzyl bromide

1,3-dibenzyldihydropyrimidine-2,4(1H,3H)-dione