(S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide

Base Information

• Chemical Name: (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide
• CAS No.: 1373493-06-1
• Molecular Formula: C₂₂H₂₃F₄N₃O₄S₂
• Molecular Weight: 533.568
• Mol file: 1373493-06-1.mol

Synonyms:

Chemical Property of (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide

There total 2 articles about (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(methylsufonyl)-4-fluorobenzene (455-15-2) + S(S)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide (1239669-98-7) → (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide (1373493-06-1)

Guidance literature:

1-(methylsufonyl)-4-fluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

S(S)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide; In tetrahydrofuran; hexane; at -45 - -20 ℃; Inert atmosphere;

DOI:10.1021/ml3000269

Reference yield:

N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide (87310-69-8) → (S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide (1373493-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 40 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: -45 - -20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/ml3000269

Reference yield:

(S(S),S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(-1,1-dimethylethylsulfinamido)-3-(4-fluorophenylsulfonyl)-2-methylpropanamide (1373493-06-1) → (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide (1239670-14-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ml3000269

upstream raw materials:

1-(methylsufonyl)-4-fluorobenzene

S(S)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide

N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide

Downstream raw materials:

(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

(S)-2-amino-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl propanamide

(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl-2-(4-methylphenylsulfonamido)propanamide

(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoro methyl)benzonitrile