(-)-tert-Butyl glycidyl ether

Base Information

• Chemical Name: (-)-tert-Butyl glycidyl ether
• CAS No.: 130232-98-3
• Molecular Formula: C7H14O2
• Molecular Weight: 130.187
• European Community (EC) Number: 812-806-7
• UNII: O65YZ0RP4G
• Nikkaji Number: J2.429.198G
• Wikidata: Q27285394
• Mol file: 130232-98-3.mol

Synonyms:130232-98-3;(-)-tert-Butyl glycidyl ether;tert-Butyl glycidyl ether, (-)-;(2R)-2-[(1,1-dimethylethoxy)methyl]Oxirane;tert-Butyl glycidyl ether, (R)-;UNII-O65YZ0RP4G;O65YZ0RP4G;Oxirane, 2-[(1,1-dimethylethoxy)methyl]-, (2R)-;(2R)-2-[(2-methylpropan-2-yl)oxymethyl]oxirane;Oxirane, ((1,1-dimethylethoxy)methyl)-, (-)-;Oxirane, ((1,1-dimethylethoxy)methyl)-, (2R)-;Oxirane, [(1,1-dimethylethoxy)methyl]-, (2R)-;Oxirane, 2-((1,1-dimethylethoxy)methyl)-, (2R)-;(R)-t-Butyl glycidyl ether;(2R)-2-(tert-Butoxymethyl)oxirane;(R)-2-t-butoxymethyl-oxiran;SCHEMBL402955;SFJRUJUEMVAZLM-ZCFIWIBFSA-N;AKOS025212740;(2R)-2-[(tert-butoxy)methyl]oxirane;CS-0056061;EN300-784645;F87055;Q27285394

Chemical Property of (-)-tert-Butyl glycidyl ether

Chemical Property:

• PSA: 21.76000
• LogP: 1.20030
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 130.099379685
• Heavy Atom Count: 9
• Complexity: 93.6

Purity/Quality:

98% ^*data from raw suppliers

(-)-Tert-Butylglycidylether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OCC1CO1
• Isomeric SMILES: CC(C)(C)OC[C@H]1CO1

Technology Process of (-)-tert-Butyl glycidyl ether

There total 3 articles about (-)-tert-Butyl glycidyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + tert-butyl alcohol (75-65-0) → (R)-tert-butyl glycidyl ether (130232-98-3)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/j.bmc.2004.06.039

Reference yield: 47.0%

t-butyl glycidyl ether (7665-72-7) → 1-tert-butoxy-3-chloro-propan-(R)-2-ol + 1-tert-butoxy-3-chloro-propan-(S)-2-ol + (S)-2-(tert-butoxymethyl)oxirane (130232-97-2) + (R)-tert-butyl glycidyl ether (130232-98-3)

Guidance literature:

With hydrogenchloride; (R,R)-[Co(salen)]2*GaCl₃; In diethyl ether; at 0 - 4 ℃; for 3h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield: 43.5%

t-butyl glycidyl ether (7665-72-7) → (S)-2-(tert-butoxymethyl)oxirane (130232-97-2) + (R)-tert-butyl glycidyl ether (130232-98-3)

Guidance literature:

With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); water; In tetrahydrofuran; acetic acid; at 0 - 20 ℃; for 20.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/op200019k

upstream raw materials:

t-butyl glycidyl ether

(S)-epichlorohydrin

tert-butyl alcohol

Downstream raw materials:

(S)-(2,3-dihydroxypropyl) phenyl sulfide