1-(4-Bromophenyl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(4-Bromophenyl)-4-methylpiperazine
• CAS No.: 130307-08-3
• Molecular Formula: C11H15BrN2
• Molecular Weight: 255.157
• Hs Code.: 2933599090
• European Community (EC) Number: 890-064-3
• DSSTox Substance ID: DTXSID60473610
• Wikidata: Q82303118
• Mol file: 130307-08-3.mol

Synonyms:1-(4-BROMOPHENYL)-4-METHYLPIPERAZINE;130307-08-3;1-(4-Bromo-phenyl)-4-methyl-piperazine;Piperazine, 1-(4-bromophenyl)-4-methyl-;1-bromo-4-(4-methyl-1-piperazinyl)benzene;MFCD09029689;SCHEMBL19402;DTXSID60473610;WCOODAWUEIXTFL-UHFFFAOYSA-N;AMY27201;AKOS015835654;CS-W007305;SB32684;AS-31479;SY004079;A22562;EN300-192151;J-503253

Chemical Property of 1-(4-Bromophenyl)-4-methylpiperazine

Chemical Property:

• Vapor Pressure: 0.00016mmHg at 25°C
• Boiling Point: 331oC at 760 mmHg
• Flash Point: 154oC
• PSA: 6.48000
• Density: 1.35g/cm3
• LogP: 2.20380
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 254.04186
• Heavy Atom Count: 14
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromophenyl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)C2=CC=C(C=C2)Br
• Uses: 1-(4-Bromophenyl)-4-methylpiperazine is a useful research chemical.

Technology Process of 1-(4-Bromophenyl)-4-methylpiperazine

There total 8 articles about 1-(4-Bromophenyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-bromophenyl)piperazine (66698-28-0) → 1-bromo-4-(4-methyl-1-piperazinyl)benzene (130307-08-3)

Guidance literature:

formaldehyd; 1-(4-bromophenyl)piperazine; With acetic acid; In methanol; water; at 20 ℃; for 18h;

With sodium cyanoborohydride; In methanol; water; at 5 - 20 ℃;

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-Bromophenyl)Piperazine Monohydrochloride → 1-bromo-4-(4-methyl-1-piperazinyl)benzene (130307-08-3)

Guidance literature:

formaldehyd; 1-(4-Bromophenyl)Piperazine Monohydrochloride; With 1,6-anhydro-2,2',3,3',4',6'-hexa-O-acetyl-β-D-lactose; In methanol; water; at 80 ℃; for 1.5h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; dichloromethane; water; for 1h; Inert atmosphere;

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-bromophenyl)piperazine hydrochloride → 1-bromo-4-(4-methyl-1-piperazinyl)benzene (130307-08-3)

Guidance literature:

formaldehyd; 1-(4-bromophenyl)piperazine hydrochloride; With acetic acid; In methanol; water; at 80 ℃; for 1.5h; Inert atmosphere;

With sodium tetrahydroborate; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

upstream raw materials:

1-(4-bromophenyl)piperazine

methyl iodide

formaldehyd

1-methyl-4-phenylpiperazine

Downstream raw materials:

6-methoxy-2-(3-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1,2,3,4-tetrahydroisoquinoline

4-(4-methyl-piperazin-1-yl)-benzenesulfinate

1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine

2-chloro-5-[4-(4-methyl-piperazin-1-yl)-benzoyl]-benzenesulfonamide