3-hydroxy-2-phenyl-1H-inden-1-one

Base Information

• Chemical Name: 3-hydroxy-2-phenyl-1H-inden-1-one
• CAS No.: 13031-53-3
• Molecular Formula: C15H10O2
• Molecular Weight: 222.243
• DSSTox Substance ID: DTXSID901300494
• Nikkaji Number: J1.365.136A

Synonyms:3-hydroxy-2-phenyl-1H-inden-1-one;CBMicro_005098;ChemDiv1_018777;3-hydroxy-2-phenylindenone;DivK1c_003561;DTXSID901300494;STK367902;2-Phenyl-3-hydroxy-1H-indene-1-one;AKOS005445210;CDS1_002521;13031-53-3

Chemical Property of 3-hydroxy-2-phenyl-1H-inden-1-one

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 222.068079557
• Heavy Atom Count: 17
• Complexity: 350

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C3=CC=CC=C3C2=O)O

Technology Process of 3-hydroxy-2-phenyl-1H-inden-1-one

There total 4 articles about 3-hydroxy-2-phenyl-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

2-benzofuran-1(3H)-one (87-41-2) + benzaldehyde (100-52-7) → 3-hydroxy-2-phenyl-1H-inden-1-one (13031-53-3)

Guidance literature:

With sodium methylate; Ethyl propionate; In methanol; at 0 ℃; Reflux;

DOI:10.1016/j.ejmech.2010.05.016

Reference yield: 57.0%

benzaldehyde (100-52-7) + potassium 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate (99682-54-9) → 3-hydroxy-2-phenyl-1H-inden-1-one (13031-53-3) + 3-(hydroxy-phenyl-methyl)-3H-isobenzofuran-1-one (92496-76-9)

Guidance literature:

With dimethyl sulfoxide; at 145 ℃; for 0.166667h;

Reference yield: 28.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 2-diazo-indan-1,3-dione (1807-49-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3-hydroxy-2-phenyl-1H-inden-1-one (13031-53-3) + 2-Methylene-3,4-dihydro-2H-indeno[1,2-b]furan-4-one

Guidance literature:

dirhodium tetraacetate; for 6h; Heating;

DOI:10.1039/b001394n

upstream raw materials:

benzaldehyde

potassium 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate

4-methyleneoxetan-2-one

2-diazo-indan-1,3-dione

Downstream raw materials:

4-benzylphthalazin-1-ol

C₂₉H₂₅F₆N₅O

C₂₇H₂₆FN₅O

C₂₈H₂₆F₃N₅O₂

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