N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Base Information

Chemical Name:N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide
CAS No.:1415798-20-7
Molecular Formula:C₂₉H₂₂F₂N₆O₄S
Molecular Weight:588.594
Hs Code.:

N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Chemical Property of N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Technology Process of N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

There total 8 articles about N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415797-75-9
4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formic acid

: 1415798-20-7
N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2.2: 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1415797-71-5
4-(4-fluorophenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-7-oxy sodium salt

: 1415798-20-7
N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylsilane; triethylamine / 3 h / 80 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

5.2: 20 °C

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

: 1415798-20-7
N-(3-fluoro-4-(2-(tetrahydropyrrole-1-formamide)pyridine-4-oxy)phenyl)-4-(4-fluoro phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 20 °C

2.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; triethylsilane; triethylamine / 3 h / 80 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

6.2: 20 °C

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;