67587-18-2Relevant academic research and scientific papers
Total Synthesis of Luminmycin A, a Cryptic Natural Product from Photorhabdus Luminescens
Servatius, Phil,Stach, Tanja,Kazmaier, Uli
, p. 3163 - 3168 (2019)
Luminmycin A, a natural proteasome inhibitor transcripted by a silent gene cluster from Photorhabdus luminescens, belongs to the compound family of the syrbactins and is structurally closely related to the glidobactins. Key step for the synthesis of the 12-membered cyclopeptide ring is an intramolecular Horner–Wadsworth–Emmons reaction, while the double unsaturated fatty acid side chain can be obtained via phosphane-catalyzed isomerization of a corresponding acetylenic fatty acid ester.
Structure-antitumor activity relationship of semi-synthetic spicamycin derivatives
Sakai,Kawai,Kamishohara,Odagawa,Suzuki,Uchida,Kawasaki,Tsuruo,Otake
, p. 1467 - 1480 (2007/10/03)
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
