[1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

Base Information

Chemical Name:[1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester
CAS No.:132246-09-4
Molecular Formula:C₂₈H₅₃N₂O₈PSi₂
Molecular Weight:632.882
Hs Code.:

[1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

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Technology Process of [1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

There total 2 articles about [1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 132246-03-8,132339-75-4
Acetic acid 1-[(2R,3S)-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl ester

: 121-45-9
phosphorous acid trimethyl ester

: 132246-09-4,132339-81-2
[1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

Guidance literature:: With titanium tetrachloride;
DOI:10.1016/S0040-4039(00)97182-X

Reference yield:

: 132245-95-5
2-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

: 132246-09-4,132339-81-2
[1-[(2R,3S)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-butyrylamino]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Pb(OAc)4 / dimethylformamide / 1) 0 deg C, 2) 0 deg C -> r.t.

2: 69 percent / TiCl₄

With lead(IV) acetate; titanium tetrachloride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)97182-X