methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle

Base Information

• Chemical Name: methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle
• CAS No.: 345230-97-9
• Molecular Formula: C₁₈H₃₄O₃Si
• Molecular Weight: 326.552
• Mol file: 345230-97-9.mol

Synonyms:

Chemical Property of methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle

There total 6 articles about methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-3,4-dihydro-2H-pyran (4454-05-1) → methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle (345230-97-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 55 percent / boron trifluoride-methanol complex / methanol / 4 h / Heating

2: 61 percent / boron trifluoride etherate / Ambient temperature

3: 95 percent / sodium acetate / acetic acid; H₂O / 4 h / Heating

4: 92 percent / NaBH₄ / methanol; H₂O / 1 h / Ambient temperature

5: 92 percent / pyridine / 0.08 h / 50 °C

6: 1.) n-BuLi, cyclohexylisopropylamine, 2.) HMPT / 1.) THF, hexane, -10 deg C, 10 min, 2.) reflux, 1.5 h

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; N-cyclohexylisopropylamine; boron trifluoride diethyl etherate; sodium acetate; boron trifluoride methanol complex; In methanol; water; acetic acid;

Reference yield:

1,1,5,5-tetramethoxy-pentane (4454-02-8) → methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle (345230-97-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 61 percent / boron trifluoride etherate / Ambient temperature

2: 95 percent / sodium acetate / acetic acid; H₂O / 4 h / Heating

3: 92 percent / NaBH₄ / methanol; H₂O / 1 h / Ambient temperature

4: 92 percent / pyridine / 0.08 h / 50 °C

5: 1.) n-BuLi, cyclohexylisopropylamine, 2.) HMPT / 1.) THF, hexane, -10 deg C, 10 min, 2.) reflux, 1.5 h

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; N-cyclohexylisopropylamine; boron trifluoride diethyl etherate; sodium acetate; In methanol; water; acetic acid;

Reference yield:

1,1,3,7,7-pentamethoxy-2,2-dimethyl-heptane (73739-61-4) → methoxy-5 methylene-2 dimethyl-6,6 cyclohexane acetate de dimethyltertiobutylsilyle (345230-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / sodium acetate / acetic acid; H₂O / 4 h / Heating

2: 92 percent / NaBH₄ / methanol; H₂O / 1 h / Ambient temperature

3: 92 percent / pyridine / 0.08 h / 50 °C

4: 1.) n-BuLi, cyclohexylisopropylamine, 2.) HMPT / 1.) THF, hexane, -10 deg C, 10 min, 2.) reflux, 1.5 h

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; N-cyclohexylisopropylamine; sodium acetate; In methanol; water; acetic acid;

upstream raw materials:

acetate d'hydroxymethyl-1 methoxy-4 dimethyl-3,3 cyclohexene-1

tert-butyldimethylsilyl chloride

2-methoxy-3,4-dihydro-2H-pyran

1,1,5,5-tetramethoxy-pentane