3-Amino-5--1-methyl-pyrazol

Base Information

• Chemical Name: 3-Amino-5--1-methyl-pyrazol
• CAS No.: 120698-01-3
• Molecular Formula: C₁₀H₁₀ClN₃
• Molecular Weight: 207.662
• Mol file: 120698-01-3.mol

Synonyms:

Chemical Property of 3-Amino-5--1-methyl-pyrazol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-5--1-methyl-pyrazol

There total 3 articles about 3-Amino-5--1-methyl-pyrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(E)-3-Chloro-3-(4-chloro-phenyl)-acrylonitrile (78583-86-5) + methylhydrazine (60-34-4) → 3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-ylamine (126417-82-1) + 3-Amino-5--1-methyl-pyrazol (120698-01-3)

Guidance literature:

In ethanol; for 5h; Heating;

Reference yield: 20.0%

(E)-3-Chloro-3-(4-chloro-phenyl)-acrylonitrile (78583-86-5) + N,N-Dimethylhydrazine (57-14-7) → (Z)-3-(4-Chloro-phenyl)-3-(N',N'-dimethyl-hydrazino)-acrylonitrile (126451-03-4,126451-04-5) + 3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-ylamine (126417-82-1) + 3-Amino-5--1-methyl-pyrazol (120698-01-3)

Guidance literature:

In ethanol; for 5h; Heating;

Reference yield:

para-chloroacetophenone (99-91-2) → 3-Amino-5--1-methyl-pyrazol (120698-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) POCl₃; 2) NH₂OH

2: 20 percent / ethanol / 5 h / Heating

With hydroxylamine; trichlorophosphate; In ethanol;

upstream raw materials:

(E)-3-Chloro-3-(4-chloro-phenyl)-acrylonitrile

N,N-Dimethylhydrazine

methylhydrazine

para-chloroacetophenone

Downstream raw materials:

5--3--4-formyl-1-methyl-pyrazol

N-[5-(4-Chloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-4-methyl-benzenesulfonamide

3-Amino-5--4-formyl-1-methyl-pyrazol

3--6,7-dihydro-5-carboxy-2-methyl-6-oxo-2H-pyrazolo<3,4-b>pyridin