460081-24-7

Basic information

• Product Name: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)
• Synonyms: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI);Ethyl2-vinyloxazole-4-carboxylate
• CAS NO: 460081-24-7
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Product Categories: GLYCINESCAFFOLD
• Mol File: 460081-24-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.37±0.10(Predicted)
• CAS DataBase Reference: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(460081-24-7)
• EPA Substance Registry System: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(460081-24-7)

Safety Data

• Hazardous Substances Data: 460081-24-7(Hazardous Substances Data)

Usage

General Description

"4-Oxazolecarboxylic acid,2-ethenyl-,ethyl ester(9CI)" is a chemical compound referred to by the registry number 102071-84-5 in the PubChem Compound Database. Due to its complex structure and organic makeup, it is often used in chemical and pharmaceutical research. 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI) is classified as a member of the Oxazolecarboxylic Acids and derivatives. As an organic ester derived from a carboxylic acid and an alcohol, it contains a carbonyl next to an ether, attributing to its reactivity. As the name suggests, it consists of an ethyl ester, which implies two carbons in the alkyl group. Safe handling of this chemical is essential, as with all chemicals, with measures in place for eye, skin, and respiratory protection. Specific details regarding its properties, functionality, and toxicity may vary by supplier and application.

Upstream product

• 75927-49-0 pinacol vinylboronate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 593-60-2 Vinyl bromide 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 70-23-5 ethyl Bromopyruvate 
• 79-06-1 2-propenamide 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 1134024-11-5 (Z)-2-(styryl)oxazole-4-carboxylic acid ethyl ester 
• 132629-37-9 ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate 
• 1015186-37-4 (E)-2-[2-(4-fluorophenyl)vinyl]oxazole-4-carboxylic acid ethyl ester 
• 1015186-17-0 (E)-2-(4-(4-methoxybenzyloxy)but-1-enyl)oxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF FERROPORTIN INHIBITORS

The invention relates to a new process for preparing compounds of the formula (I) and pharmaceutically acceptable salts thereof, which act as ferroportin inhibitors being suitable for the use as medicaments in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or of iron metabolism disorders leading to increased iron levels or increased iron absorption, including iron overload, thalassemia, sickle cell disease and hemochromatosis.

Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis

(Chemical Equation Presented) A ruthenium-based catalyzed olefin cross-methathesis reaction involving 2- and 4-vinyl-functionalized oxazoles was developed. A wide range of olefinic partners was coupled in good to excellent yields and high stereoselectivities under mild conditions. This methodology offers new opportunities for the synthesis of a plethora of biologically active natural products.

Ethyl 2-chlorooxazole-4-carboxylate: A versatile intermediate for the synthesis of substituted oxazoles

(formula presented) R1 = Ar, Het, alkenyl R2 = H, Ar, Het, alkenyl, alkynyl R3 = H, CO2H, Ar, Het, alkenyl, alkynyl By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions,