460081-24-7

Basic information

• Product Name: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)
• Synonyms: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI);Ethyl2-vinyloxazole-4-carboxylate
• CAS NO: 460081-24-7
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Product Categories: GLYCINESCAFFOLD
• Mol File: 460081-24-7.mol

Chemical Properties

• Boiling Point: 258.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.37±0.10(Predicted)
• CAS DataBase Reference: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(460081-24-7)
• EPA Substance Registry System: 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI)(460081-24-7)

Safety Data

• Hazardous Substances Data: 460081-24-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
4-Oxazolecarboxylic acid,2-ethenyl-,ethyl ester(9CI) is used as a research compound for its complex structure and organic makeup, contributing to the advancement of chemical science.
Used in Pharmaceutical Research:
4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI) is utilized as a pharmaceutical intermediate, potentially playing a role in the development of new drugs due to its unique chemical properties and reactivity.
Used in Drug Synthesis:
4-Oxazolecarboxylic acid,2-ethenyl-,ethyl ester(9CI) is used as a building block in the synthesis of various pharmaceutical compounds, leveraging its reactivity and structural features to create new drug candidates.
Used in Material Science:
In the field of material science, 4-Oxazolecarboxylicacid,2-ethenyl-,ethylester(9CI) may be employed as a component in the development of novel materials, taking advantage of its chemical properties to enhance material performance.

Upstream product

• 70-23-5 ethyl Bromopyruvate 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 593-60-2 Vinyl bromide 
• 75927-49-0 pinacol vinylboronate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 79-06-1 2-propenamide 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 132629-37-9 ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate 
• 1134024-11-5 (Z)-2-(styryl)oxazole-4-carboxylic acid ethyl ester 
• 1015186-37-4 (E)-2-[2-(4-fluorophenyl)vinyl]oxazole-4-carboxylic acid ethyl ester 
• 1015186-17-0 (E)-2-(4-(4-methoxybenzyloxy)but-1-enyl)oxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF FERROPORTIN INHIBITORS

The invention relates to a new process for preparing compounds of the formula (I) and pharmaceutically acceptable salts thereof, which act as ferroportin inhibitors being suitable for the use as medicaments in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or of iron metabolism disorders leading to increased iron levels or increased iron absorption, including iron overload, thalassemia, sickle cell disease and hemochromatosis.

Stereoselective synthesis of the C1-C11 and C12-C34 fragments of mycalolide A

(Equation Presented). A convergent synthesis of the C1-C11 and C12-C34 fragments of mycalolide A is described. Synthetic highlights include a highly E-selective cross-metathesis between a vinyl-functionalized bis-oxazole unit and a polypropionate side cha

Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis

(Chemical Equation Presented) A ruthenium-based catalyzed olefin cross-methathesis reaction involving 2- and 4-vinyl-functionalized oxazoles was developed. A wide range of olefinic partners was coupled in good to excellent yields and high stereoselectivities under mild conditions. This methodology offers new opportunities for the synthesis of a plethora of biologically active natural products.

Preparation and reactivity of ethyl 2-vinyloxazole-4-carboxylate

The one-step synthesis of ethyl 2-vinyloxazole-4-carboxylate is described. The reactivity of this synthetically useful oxazole fragment towards addition and Heck coupling was examined.

Ethyl 2-chlorooxazole-4-carboxylate: A versatile intermediate for the synthesis of substituted oxazoles

(formula presented) R1 = Ar, Het, alkenyl R2 = H, Ar, Het, alkenyl, alkynyl R3 = H, CO2H, Ar, Het, alkenyl, alkynyl By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions,