4-fluorophenylbutyric acid

Base Information

• Chemical Name: 4-fluorophenylbutyric acid
• CAS No.: 7139-24-4
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Mol file: 7139-24-4.mol

Synonyms:

Chemical Property of 4-fluorophenylbutyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluorophenylbutyric acid

There total 6 articles about 4-fluorophenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

carbon dioxide (124-38-9,18923-20-1) + 1-fluoro-4-(prop-1-en-1-yl)benzene (699-01-4) → 4-fluorophenylbutyric acid (7139-24-4,90794-16-4)

Guidance literature:

1-fluoro-4-(prop-1-en-1-yl)benzene; With 9-borabicyclo[3.3.1]nonane dimer; In 1,2-dimethoxyethane; at 70 ℃; for 24h; Glovebox;

carbon dioxide; With cesium fluoride; In 1,2-dimethoxyethane; at 120 ℃; for 24h; regioselective reaction; Glovebox;

DOI:10.1039/c9sc02467k

Reference yield:

ethyl bromide (74-96-4) + p-Fluorophenylacetic acid (405-50-5) → 4-fluorophenylbutyric acid (7139-24-4,90794-16-4)

Guidance literature:

p-Fluorophenylacetic acid; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - 25 ℃;

ethyl bromide; In tetrahydrofuran; hexanes; at 20 - 25 ℃; for 16h;

DOI:10.1002/adsc.200900538

Reference yield:

ethyl iodide (75-03-6) + p-Fluorophenylacetic acid (405-50-5) → 4-fluorophenylbutyric acid (7139-24-4,90794-16-4)

Guidance literature:

p-Fluorophenylacetic acid; With n-butyllithium; In tetrahydrofuran; hexanes; at 0 ℃; for 0.166667h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; hexanes; Inert atmosphere;

DOI:10.1021/ja205107x

upstream raw materials:

2-(4-fluorophenyl)butanenitrile

ethyl bromide

p-Fluorophenylacetic acid

ethyl iodide

Downstream raw materials:

dl-2-(4-Fluorphenyl)butanol

2-(4-fluorophenyl)but-1-en-1-one

2-(4-fluorophenyl)-N-(2-(pyrrolidin-1-yl)phenyl)butanamide