N-methylamide of D-(-)-mandelic acid

Base Information

• Chemical Name: N-methylamide of D-(-)-mandelic acid
• CAS No.: 2019-72-9
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Mol file: 2019-72-9.mol

Synonyms:

Chemical Property of N-methylamide of D-(-)-mandelic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methylamide of D-(-)-mandelic acid

There total 22 articles about N-methylamide of D-(-)-mandelic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzaldehyde (100-52-7) + methylamine (74-89-5) + 2-hydroxypropanedinitrile (20342-65-8) → N-methyl-2-hydroxy-2-phenylethanamide (65645-88-7,89843-35-6,96392-41-5,2019-72-9)

Guidance literature:

With acetic acid; In methanol; at 50 ℃; for 0.166667h;

Reference yield: 75.0%

N-methoxy-N-methyl-α-oxo-benzeneacetamide (141694-25-9) → (S)-2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide (1391068-07-7) + N-methyl-2-hydroxy-2-phenylethanamide (65645-88-7,89843-35-6,96392-41-5,2019-72-9)

Guidance literature:

With dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; (S)-SunPhos; hydrogen; In ethanol; at 70 ℃; for 20h; enantioselective reaction; Schlenk technique; Autoclave;

DOI:10.1007/s11426-012-4790-8

Reference yield: 55.0%

N-(Mesyloxy)-N-methylphenylacetanilide (142437-76-1) → N-methyl-2-hydroxy-2-phenylethanamide (65645-88-7,89843-35-6,96392-41-5,2019-72-9)

Guidance literature:

With water; triethylamine; In acetonitrile;

DOI:10.1021/ja00041a064

upstream raw materials:

N-acetyl-N'-methylurea

hydroxy-phenyl-acetic acid ethyl ester

(RS)-methyl mandelate

methylamine

Downstream raw materials:

(+/-)-O,N-Bis(trimethylsilyl)mandelsaeure-methylamid

2-trimethylsilyloxy-2-phenylacetic acid N-methylamide

(N-methylcarbamoyl)(phenyl)methyl acetate

2,3-Dimethyl-5-phenyl-1,3-oxazolidin-4-on