C₂₈H₂₉N₅O₄

Base Information

• Chemical Name: C₂₈H₂₉N₅O₄
• CAS No.: 1373354-33-6
• Molecular Formula: C₂₈H₂₉N₅O₄
• Molecular Weight: 499.569
• Mol file: 1373354-33-6.mol

Synonyms:

Chemical Property of C₂₈H₂₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₉N₅O₄

There total 9 articles about C₂₈H₂₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (1300031-58-6,1300737-70-5) → C28H29N5O4 (1373354-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 4 h / Heating

2: ammonium hydroxide / tetrahydrofuran / 0.5 h / Cooling with ice

3: Heating

With ammonium hydroxide; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

3,5-dimethylisoxazole-4-boronic acid (16114-47-9) → C28H29N5O4 (1373354-33-6)

Guidance literature:

Multi-step reaction with 8 steps

1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

3: 1 h / 130 °C

4: diphenylether / 0.75 h / 255 °C

5: sodium hydroxide / ethanol / Reflux

6: trichlorophosphate / 4 h / Heating

7: ammonium hydroxide / tetrahydrofuran / 0.5 h / Cooling with ice

8: Heating

With ammonium hydroxide; diphenylether; palladium on activated charcoal; hydrogen; caesium carbonate; sodium hydroxide; sodium sulfite; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole (1300031-62-2) → C28H29N5O4 (1373354-33-6)

Guidance literature:

Multi-step reaction with 7 steps

1: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

2: 1 h / 130 °C

3: diphenylether / 0.75 h / 255 °C

4: sodium hydroxide / ethanol / Reflux

5: trichlorophosphate / 4 h / Heating

6: ammonium hydroxide / tetrahydrofuran / 0.5 h / Cooling with ice

7: Heating

With ammonium hydroxide; diphenylether; palladium on activated charcoal; hydrogen; sodium hydroxide; sodium sulfite; trichlorophosphate; In tetrahydrofuran; ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2012.01.125

upstream raw materials:

3,5-dimethylisoxazole-4-boronic acid

3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole

[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine

1,3-diethyl 2-([[3-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxyphenyl]amino]methylidene)propanedioate