Technology Process of C24H27N5O4
There total 4 articles about C24H27N5O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-acetyl-D-tryptophan;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
Schlenk technique;
H-L-Phe-Gly-NH2;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 80 ℃;
for 0.166667h;
Inert atmosphere;
Schlenk technique;
Microwave irradiation;
DOI:10.1021/jm5002925
- Guidance literature:
-
N-tert-butoxycarbonyl-L-phenylalanine; glycinamide hydrochloride;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.5h;
Inert atmosphere;
N-acetyl-D-tryptophan;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm301213s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: porcine kidney L-acylase; cobalt(II) chloride hexahydrate / aq. phosphate buffer / 24 h / 37 °C / pH 7.4 / Enzymatic reaction
2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 0.17 h / 80 °C / Inert atmosphere; Schlenk technique; Microwave irradiation
With
cobalt(II) chloride hexahydrate; porcine kidney L-acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;
In
aq. phosphate buffer; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5002925