(R)-(+)-1-(3-methoxyphenyl)-1-ethanol

Base Information

• Chemical Name: (R)-(+)-1-(3-methoxyphenyl)-1-ethanol
• CAS No.: 89691-63-4
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.193
• Mol file: 89691-63-4.mol

Synonyms:

Chemical Property of (R)-(+)-1-(3-methoxyphenyl)-1-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-1-(3-methoxyphenyl)-1-ethanol

There total 140 articles about (R)-(+)-1-(3-methoxyphenyl)-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C15H23BO4 → 1-(3-methoxy)-phenylethanol (89691-63-4,120523-12-8,129940-69-8,23308-82-9)

Guidance literature:

With silica gel; at 25 ℃; Inert atmosphere; Glovebox;

DOI:10.1021/acs.joc.8b01094

Reference yield: 90.0%

isopropyl alcohol (67-63-0,8013-70-5) + 1-(3-Methoxyphenyl)ethanone (586-37-8) → 1-(3-methoxy)-phenylethanol (89691-63-4,120523-12-8,129940-69-8,23308-82-9) + acetone (67-64-1)

Guidance literature:

With [RuCl₂(triphenylphosphine)((6-((3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl)methylene)-p-tolyl-amine)]*0.5Et₂O; potassium isopropoxide; at 82 ℃; for 2.16667h; under 750.075 Torr; Inert atmosphere;

DOI:10.1016/j.jorganchem.2009.05.028

Reference yield: 83.0%

3-methoxystyrene (626-20-0) → 1-(3-methoxy)-phenylethanol (89691-63-4,120523-12-8,129940-69-8,23308-82-9)

Guidance literature:

3-methoxystyrene; With iron(II) chloride tetrahydrate; N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h; Inert atmosphere;

In tetrahydrofuran; diethyl ether; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol5029892

upstream raw materials:

methyl magnesium iodide

3-methoxy-benzaldehyde

1-(3-Methoxyphenyl)ethanone

1-chloro-1-(3'-methoxyphenyl)ethane

Downstream raw materials:

3-methoxystyrene

S-(-)-1-(3-methoxyphenyl)ethanol