1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide

Base Information

• Chemical Name: 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide
• CAS No.: 106836-00-4
• Molecular Formula: C₈H₁₇NOSi
• Molecular Weight: 171.315
• Mol file: 106836-00-4.mol

Synonyms:

Chemical Property of 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide

There total 1 articles about 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1,2-epoxypropane (558-30-5) + trimethylsilyl cyanide (7677-24-9) → 3-methyl-2-(trimethylsilyloxy)butanenitrile (40326-16-7) + 2-<(trimethylsilyl)oxy>butanenitrile (24731-32-6) + 3-methyl-3-<(trimethylsilyl)oxy>butyronitrile (14904-41-7) + 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide (106836-00-4)

Guidance literature:

With diethylaluminium chloride; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) heptane, RT, 15 min, 2.) heptane;

DOI:10.1021/jo00382a008

Reference yield: 60.0%

triphenylborane (960-71-4) + 1,1-dimethyl-2-(trimethylsiloxy)ethyl isocyanide (106836-00-4) → (C6H5)3BCNC(CH3)2CH2OSi(CH3)3 (125669-22-9)

Guidance literature:

In dichloromethane; (Ar); addn. of CNC(Me)2CH2OSiMe3 to a stirred soln. of Ph3B in CH2Cl2; warming up of react. mixture; stirring for 30 min; removal of solvent; addn. of diethylether/petrolether; stirring for 15 min; filtn.; drying for 2 h at high-vac.; elem. anal.;

upstream raw materials:

2-methyl-1,2-epoxypropane

trimethylsilyl cyanide

Downstream raw materials:

(C₆H₅)3BCNC(CH₃)2CH₂OSi(CH₃)3

Refernces