1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl-

Base Information

• Chemical Name: 1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl-
• CAS No.: 133788-00-8
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• DSSTox Substance ID: DTXSID70437485
• Nikkaji Number: J495.911F
• Mol file: 133788-00-8.mol

Synonyms:133788-00-8;1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl-;2-phenyl-7-oxabicyclo[3.3.0]oct-1-en-3-one;SCHEMBL18980702;DTXSID70437485;AKOS015904812;2-Phenyl-3-oxo-7-oxabicyclo[3.3.0]octane-1-ene;6-phenyl-1,3,3a,4-tetrahydro-cyclopenta[c]furan-5-one;6-phenyl-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one

Chemical Property of 1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl-

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 311

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2COCC2=C(C1=O)C3=CC=CC=C3

Technology Process of 1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl-

There total 49 articles about 1H-Cyclopenta[c]furan-5(3H)-one, 3a,4-dihydro-6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon monoxide (201230-82-2) + 3-(allyloxy)-1-phenyl-2-propyne (53877-58-0) → 6-phenyl-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one (133788-00-8)

Guidance literature:

With dicobalt octacarbonyl; In toluene; at 170 ℃; for 0.45h; under 15001.5 Torr; Temperature; Flow reactor;

DOI:10.1039/c7cc01749a

Reference yield: 98.0%

3-(allyloxy)-1-phenyl-2-propyne (53877-58-0) + 2-pyridylmethyl formate (401515-97-7) → 6-phenyl-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one (133788-00-8)

Guidance literature:

cobalt nanoparticles immobilized on charcoal; ruthenium; In tetrahydrofuran; at 130 ℃; for 18h;

DOI:10.1039/b304325h

Reference yield: 98.0%

3-(allyloxy)-1-phenyl-2-propyne (53877-58-0) + 3-phenyl-propenal (104-55-2) → 6-phenyl-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one (133788-00-8)

Guidance literature:

Rh(dppp)2Cl; at 120 ℃; for 2h;

DOI:10.1021/jo0262661

upstream raw materials:

trimethylsilyl cyanide

3-(allyloxy)-1-phenyl-2-propyne

carbon monoxide

(triisopropyl)silyl cyanide