tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate

Base Information

• Chemical Name: tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate
• CAS No.: 1271728-79-0
• Molecular Formula: C₁₁H₂₁N₃O₄
• Molecular Weight: 259.305
• Mol file: 1271728-79-0.mol

Synonyms:

Chemical Property of tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azido-PEG2-t-butylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG2- t-butyl ester is a azide containing PEG compound. The azide (N3) group is reactive with BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate

There total 6 articles about tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

9-(p-toluenesulfonyloxy)-3,6-diocanonanoic acid tert-butyl ester (850090-13-0) → tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate (1271728-79-0)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 10h;

DOI:10.1002/cbic.202100243

Reference yield: 87.0%

tert-butyl 3-(2-(2-((methylsulfonyl)oxy)ethoxy)ethoxy)propanoate (1312309-62-8) → tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate (1271728-79-0)

Guidance literature:

With sodium azide; In N,N-dimethyl acetamide; at 80 ℃; for 4h;

Reference yield: 78.0%

2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate (133803-81-3,892154-71-1) → tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate (1271728-79-0)

Guidance literature:

With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; toluene; at 50 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ja1083915

upstream raw materials:

2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate

9-(p-toluenesulfonyloxy)-3,6-diocanonanoic acid tert-butyl ester

tert-Butyl acrylate

tert-butyl 3-(2-(2-((methylsulfonyl)oxy)ethoxy)ethoxy)propanoate

Downstream raw materials:

3-(2-(2-azidoethoxy)ethoxy)propanoic acid

2,5-dioxopyrrolidin-1-yl-3 (2-(2-azidoethoxy)ethoxy)propanoate