Technology Process of 2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-3-{[4-(pyrrolidin-1-yl)piperidin-1-yl]methyl}-1H-indole
There total 8 articles about 2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-3-{[4-(pyrrolidin-1-yl)piperidin-1-yl]methyl}-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethanol / 3 h / 80 °C
2.1: potassium hydroxide / water / 2 h / 110 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C
3.2: 20 °C
4.1: trichlorophosphate / -5 °C
4.2: 1 h / 55 °C
5.1: acetic acid / tetrahydrofuran / 0.1 h
5.2: 4 h / 20 °C
With
potassium carbonate; acetic acid; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
4.1: |Vilsmeier-Haack Formylation / 4.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: hydrogenchloride; sodium nitrite; tin(ll) chloride / -5 - 20 °C
2.1: acetic acid / ethanol / 1 h / 80 °C
3.1: polyphosphoric acid / toluene / 5 h / 100 °C
4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C
5.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C
6.1: ethanol / 3 h / 80 °C
7.1: potassium hydroxide / water / 2 h / 110 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C
8.2: 20 °C
9.1: trichlorophosphate / -5 °C
9.2: 1 h / 55 °C
10.1: acetic acid / tetrahydrofuran / 0.1 h
10.2: 4 h / 20 °C
With
hydrogenchloride; sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; tin(ll) chloride; potassium hydroxide; sodium nitrite; trichlorophosphate;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
9.1: |Vilsmeier-Haack Formylation / 9.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: acetic acid / ethanol / 1 h / 80 °C
2.1: polyphosphoric acid / toluene / 5 h / 100 °C
3.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C
4.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C
5.1: ethanol / 3 h / 80 °C
6.1: potassium hydroxide / water / 2 h / 110 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C
7.2: 20 °C
8.1: trichlorophosphate / -5 °C
8.2: 1 h / 55 °C
9.1: acetic acid / tetrahydrofuran / 0.1 h
9.2: 4 h / 20 °C
With
sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
8.1: |Vilsmeier-Haack Formylation / 8.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018
