rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate

Base Information

• Chemical Name: rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate
• CAS No.: 1075221-64-5
• Molecular Formula: C₂₀H₂₆F₂N₂O₆S
• Molecular Weight: 460.499
• Mol file: 1075221-64-5.mol

Synonyms:

Chemical Property of rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate

There total 1 articles about rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

methanol (67-56-1) + (acetylthio)acetyl chloride (10553-78-3) + rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride (1075221-43-0) + di-tert-butyl dicarbonate (24424-99-5) → rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate (1075221-64-5) + rac-ethyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate (1075221-63-4)

Guidance literature:

rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride; di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

methanol;

(acetylthio)acetyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.200800363

upstream raw materials:

methanol

(acetylthio)acetyl chloride

rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

di-tert-butyl dicarbonate