rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

Base Information

Chemical Name:rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride
CAS No.:1075221-43-0
Molecular Formula:C₁₂H₁₆F₂N₂O₂*ClH
Molecular Weight:294.729
Hs Code.:

Synonyms:rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

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Chemical Property of rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

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Technology Process of rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

There total 1 articles about rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1075221-38-3
rac-benzyl 4-[1-(dibenzylamino)-2-(ethoxycarbonyl)-2,2-difluoroethyl]benzylcarbamate

: 1075221-43-0
rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

Guidance literature:: With hydrogenchloride; 10% Pd/C; hydrogen; In ethanol; ethyl acetate; isopropyl alcohol; at 40 ℃; for 72h; under 760.051 Torr;
DOI:10.1002/ejoc.200800363

Reference yield: 34.0%

: 67-56-1
methanol

: 10553-78-3
(acetylthio)acetyl chloride

: 1075221-43-0
rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 1075221-64-5
rac-methyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate

: 1075221-63-4
rac-ethyl 3-{[(acetylsulfanyl)acetyl]amino}-3-(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)-2,2-difluoropropionate

Guidance literature:: rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride; di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

methanol;

(acetylthio)acetyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/ejoc.200800363

Reference yield:

: 67-56-1
methanol

: 1075221-43-0
rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 1075221-45-2
rac-benyzl 4-[1-amino-2-(methoxycarbonyl)-2,2-difluoroethyl]benzylcarbamate

: 1075221-44-1
rac-benyzl 4-[1-amino-2-(ethoxycarbonyl)-2,2-difluoroethyl]benzylcarbamate

Guidance literature:: rac-ethyl 3-amino-3-[4-(aminomethyl)phenyl]-2,2-difluoropropanoate hydrochloride; di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

methanol;
DOI:10.1002/ejoc.200800363