Tos-PEG2-CH2CO2tBu

Base Information

• Chemical Name: Tos-PEG2-CH2CO2tBu
• CAS No.: 1643957-24-7
• Molecular Formula: C₁₅H₂₂O₆S
• Molecular Weight: 330.402
• Mol file: 1643957-24-7.mol

Synonyms:

Chemical Property of Tos-PEG2-CH2CO2tBu

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

Tos-PEG2-CH2CO2tBu 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of Tos-PEG2-CH2CO2tBu

There total 3 articles about Tos-PEG2-CH2CO2tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-toluenesulfonyl chloride (98-59-9) + (2-hydroxyethoxy)acetic acid tert-butyl ester (287174-32-7) → tert-butyl 2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate (1643957-24-7)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl 2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate (1643957-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

1.2: 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

3.1: pyridine / 16 h / 20 °C

With pyridine; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In ethanol; tert-butyl alcohol;

Reference yield:

2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester (1309451-06-6) → tert-butyl 2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate (1643957-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

2: pyridine / 16 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; In ethanol;

upstream raw materials:

p-toluenesulfonyl chloride

(2-hydroxyethoxy)acetic acid tert-butyl ester

bromoacetic acid tert-butyl ester

2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester