NH-(PEG3-t-butyl ester)2

Base Information

• Chemical Name: NH-(PEG3-t-butyl ester)2
• CAS No.: 1814901-03-5
• Molecular Formula: C₂₆H₅₁NO₁₀
• Molecular Weight: 537.692
• Mol file: 1814901-03-5.mol

Synonyms:

Chemical Property of NH-(PEG3-t-butyl ester)2

Chemical Property:

• Boiling Point: 564.7±45.0 °C(Predicted)
• PKA: 8.39±0.19(Predicted)
• Density: 1.050±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

97% ^*data from raw suppliers

NH-bis(PEG3-t-butylester) 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: NH-bis(PEG3-t-butyl ester) is a PEG linker containing an amino group and 3 PEG units. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of NH-(PEG3-t-butyl ester)2

There total 5 articles about NH-(PEG3-t-butyl ester)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate (252881-73-5) → tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) + aminobis(4,7,10-trioxadodecanoic acid tert-butyl ester) (1814901-03-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; under 1520.1 Torr;

Reference yield:

3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester (186020-66-6,892154-71-1) → aminobis(4,7,10-trioxadodecanoic acid tert-butyl ester) (1814901-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / acetonitrile / 5.5 h

2: sodium azide / N,N-dimethyl-formamide / 20 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C / 1520.1 Torr

With pyridine; sodium azide; palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate (217817-01-1) → aminobis(4,7,10-trioxadodecanoic acid tert-butyl ester) (1814901-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 20 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C / 1520.1 Torr

With sodium azide; palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester

tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate

tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate

tert-Butyl acrylate

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