2-Bromo-N-methoxy-N-methylacetamide

Base Information

• Chemical Name: 2-Bromo-N-methoxy-N-methylacetamide
• CAS No.: 134833-83-3
• Molecular Formula: C4H8BrNO2
• Molecular Weight: 182.017
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID50446373
• Nikkaji Number: J1.271.810A
• Wikidata: Q82264998
• Mol file: 134833-83-3.mol

Synonyms:2-Bromo-N-methoxy-N-methylacetamide;134833-83-3;2-BROMO-N-METHOXY-N-METHYL ACETAMIDE;2-bromo-N-methoxy-N-methyl-acetamide;MFCD11044961;Acetamide, 2-bromo-N-methoxy-N-methyl-;SCHEMBL2166384;N-Methyl-N-methoxybromoacetamide;DTXSID50446373;GKJMVMJIDBDPDZ-UHFFFAOYSA-N;bromo-N-methyl-N-methoxy-acetamide;N-methyl-N-methoxy 2-bromoacetamide;BBL103480;STL557290;AKOS012992120;n-methoxy-n-methyl-2-bromo-ethanamide;MS-20635;EN300-1252475

Chemical Property of 2-Bromo-N-methoxy-N-methylacetamide

Chemical Property:

• Boiling Point: 158.7±42.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.536±0.06 g/cm3(Predicted)
• LogP: 0.40110
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 180.97384
• Heavy Atom Count: 8
• Complexity: 86.1

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-N-methoxy-N-methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C(=O)CBr)OC

Technology Process of 2-Bromo-N-methoxy-N-methylacetamide

There total 3 articles about 2-Bromo-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-methoxy-N-methyl-acetamide (134833-83-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1039/b904363b

Reference yield: 70.0%

2-Bromoacetyl bromide (598-21-0) + N,0-dimethylhydroxylamine (1117-97-1) → 2-bromo-N-methoxy-N-methyl-acetamide (134833-83-3)

Guidance literature:

With potassium carbonate; In diethyl ether; water; for 2.33333h; Inert atmosphere; Cooling with ice;

DOI:10.1021/ml500284k

Reference yield:

2-bromoacetyl chloride (22118-09-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-bromo-N-methoxy-N-methyl-acetamide (134833-83-3)

Guidance literature:

With pyridine; In dichloromethane;

upstream raw materials:

2-Bromoacetyl bromide

N,0-dimethylhydroxylamine

N,O-dimethylhydroxylamine*hydrochloride

2-bromoacetyl chloride

Downstream raw materials:

2-(2-(1,3-dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)ethoxy)-N-methoxy-N-methylacetamide

2-((1-((tert-butyldimethylsilyl)oxy)-3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propan-2-yl)oxy)-N-methoxy-N-methylacetamide

2-(allyloxy)-N-methoxy-N-methylacetamide