2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin

Base Information

• Chemical Name: 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin
• CAS No.: 84941-62-8
• Molecular Formula: C₁₄H₁₆N₂
• Molecular Weight: 212.294

Synonyms:

Chemical Property of 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin

Chemical Property:

Purity/Quality:

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Technology Process of 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin

There total 6 articles about 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-Phenyl-5,6,7,8,9,9a-hexahydro-3H-imidazo<1,2-a>azepin-1-oxid (42564-24-9) → 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin (84941-62-8) + 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin-1-oxid (84941-61-7)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III); In water; for 1h; Product distribution; other oxidation agents;

DOI:10.1002/ardp.19833160111

Reference yield:

acetophenone (98-86-2) → 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin (84941-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine / chloroform / 6 h / 0 - 25 °C / Inert atmosphere

2: hydrogenchloride / ethanol / 25 °C / Inert atmosphere

3: sodium carbonate / dichloromethane / 2 h / 25 °C / Inert atmosphere

4: triethylamine / dimethyl sulfoxide / 7 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube; Irradiation

With hydrogenchloride; bromine; sodium carbonate; triethylamine; In ethanol; dichloromethane; chloroform; dimethyl sulfoxide;

DOI:10.1021/acs.orglett.7b00533

Reference yield:

α-bromoacetophenone (70-11-1) → 2-Phenyl-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepin (84941-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 25 °C / Inert atmosphere

2: sodium carbonate / dichloromethane / 2 h / 25 °C / Inert atmosphere

3: triethylamine / dimethyl sulfoxide / 7 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube; Irradiation

With hydrogenchloride; sodium carbonate; triethylamine; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/acs.orglett.7b00533

upstream raw materials:

2-Phenyl-5,6,7,8,9,9a-hexahydro-3H-imidazo<1,2-a>azepin-1-oxid

1-hydroxy-2-phenyl-perhydroimidazo[1,2-a]azepine

acetophenone

α-bromoacetophenone

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