(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one

Base Information

• Chemical Name: (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one
• CAS No.: 1160521-39-0
• Molecular Formula: C₂₃H₂₈N₆O
• Molecular Weight: 404.515
• Mol file: 1160521-39-0.mol

Synonyms:

Chemical Property of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one

There total 8 articles about (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

cyclopentylmethyl Iodide (27935-87-1) + (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one → (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one (1160521-39-0)

Guidance literature:

With caesium carbonate; In butanone; at 140 ℃; for 0.5h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

5-methyl-3-(phenylamino)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione → (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one (1160521-39-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 48 h / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

3: thionyl chloride / dichloromethane; tetrahydrofuran / 20 °C / Inert atmosphere

4: caesium carbonate / butanone / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With thionyl chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butanone;

DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

6-((1R,2R)-2-hydroxycyclopentylamino)-5-methyl-3-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one → (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-1-(cyclopentylmethyl)-5-methyl-3-phenylaminocyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one (1160521-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane; tetrahydrofuran / 20 °C / Inert atmosphere

2: caesium carbonate / butanone / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With thionyl chloride; caesium carbonate; In tetrahydrofuran; dichloromethane; butanone;

DOI:10.1021/acs.jmedchem.5b01751

upstream raw materials:

6-chloro-5-methyl-3-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

cyclopentylmethyl Iodide

3-methyl-6-chlorouracil

6-chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione