Belizatinib

Base Information

Chemical Name:Belizatinib
CAS No.:1357920-84-3
Molecular Formula:C₃₃H₄₄FN₅O₃
Molecular Weight:577.742
Hs Code.:
Mol file:1357920-84-3.mol

Synonyms:

Suppliers and Price of Belizatinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Belizatinib(TSR-011) >98%
1 g
$ 2100.00

DC Chemicals
Belizatinib(TSR-011) >98%
250 mg
$ 1100.00

ChemScene
Belizatinib 99.66%
25mg
$ 390.00

ChemScene
Belizatinib 99.66%
10mg
$ 200.00

ChemScene
Belizatinib 99.66%
5mg
$ 120.00

ChemScene
Belizatinib 99.66%
2mg
$ 60.00

ChemScene
Belizatinib 99.66%
100mg
$ 750.00

ChemScene
Belizatinib 99.66%
50mg
$ 560.00

Cayman Chemical
Belizatinib
25mg
$ 399.00

Cayman Chemical
Belizatinib
1mg
$ 29.00

Total 11 raw suppliers

Chemical Property of Belizatinib

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Belizatinib(TSR-011) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Belizatinib, also known as TSR-011, is an oral inhibitor of ALK and TRK. Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).
Uses Belizatinib is used in treating diseases via targeted modulation of gene signaling networks.

Technology Process of Belizatinib

There total 8 articles about Belizatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

: 22990-34-7
2-(piperidin-4-yl)propan-2-ol

: C₂₅H₂₈ClFN₄O₂

: 1357920-84-3,1388225-72-6
(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: C₂₅H₂₈ClFN₄O₂; In acetonitrile; at 20 ℃;

2-(piperidin-4-yl)propan-2-ol; With thionyl chloride; at 0 ℃;
DOI:10.1021/jm3005866

Reference yield:

: 503315-74-0
(3-fluoro-4-nitrophenyl)methanol

: 1357920-84-3,1388225-72-6
(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 80 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 60 °C

4.1: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

5.1: acetonitrile / 20 °C

5.2: 0 °C

With thionyl chloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm3005866

Reference yield:

: 1357924-77-6
(1s,4s)-4-(2-amino-5-(hydroxymethyl)phenylamino)-N-isopropylcyclohexanecarboxamide

: 1357920-84-3,1388225-72-6
(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 60 °C

2.1: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

3.1: acetonitrile / 20 °C

3.2: 0 °C

With thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm3005866