diethyl quinoline-2,4-dicarboxylate

Base Information

• Chemical Name: diethyl quinoline-2,4-dicarboxylate
• CAS No.: 25635-39-6
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.288
• Mol file: 25635-39-6.mol

Synonyms:

Chemical Property of diethyl quinoline-2,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl quinoline-2,4-dicarboxylate

There total 1 articles about diethyl quinoline-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) + quinoline (91-22-5) → ethyl quinoline-4-carboxylate (10447-29-7) + ethyl quinoline-2-carboxylate (4491-33-2) + diethyl quinoline-2,4-dicarboxylate (25635-39-6)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; In dichloromethane; water; at -10 - 0 ℃; for 0.25h; Product distribution; Variation of mole ratio of the base and the peroxide.;

DOI:10.1016/S0040-4020(01)96080-6

Reference yield:

diethyl quinoline-2,4-dicarboxylate (25635-39-6) → 2-amino-quinoline-4-carboxylic acid (157915-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol. NH₃ / 50 °C

2: bromine; aqueous KOH

With potassium hydroxide; ammonia; bromine;

DOI:10.1021/ja01267a025

upstream raw materials:

2-oxo-propionic acid ethyl ester

quinoline

Downstream raw materials:

2-amino-quinoline-4-carboxylic acid