H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH₂*2HCl

Base Information

• Chemical Name: H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH₂*2HCl
• CAS No.: 123622-30-0
• Molecular Formula: C₄₅H₆₂N₈O₈S*2ClH
• Molecular Weight: 948.024
• Mol file: 123622-30-0.mol

Synonyms:

Chemical Property of H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH₂*2HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH₂*2HCl

There total 16 articles about H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH₂*2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride (103321-57-9) → H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH2*2HCl (123622-30-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

2: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

3: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

4: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

5: 1) 15percent NH₃, 2) 0.1 N HCl / 1) 40 h, room temperature, MeOH, 2) DMF

With hydrogenchloride; ammonium hydroxide; sodium carbonate; 4-Aminomethylpiperidine; In chloroform;

DOI:10.1021/jo00289a056

Reference yield:

N-Fmoc L-Phe (35661-40-6) → H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH2*2HCl (123622-30-0)

Guidance literature:

Multi-step reaction with 6 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / Heating

2: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

3: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

4: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

5: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

6: 1) 15percent NH₃, 2) 0.1 N HCl / 1) 40 h, room temperature, MeOH, 2) DMF

With hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium carbonate; 4-Aminomethylpiperidine; In dichloromethane; chloroform;

DOI:10.1021/jo00289a056

Reference yield:

Fmoc-Leu-OH (35661-60-0) → H-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH2*2HCl (123622-30-0)

Guidance literature:

Multi-step reaction with 12 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / Heating

2: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

3: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

4: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

5: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

6: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

7: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

8: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

9: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

10: 5percent Na₂CO₃ / CHCl₃ / 0.17 h

11: 4-(aminomethyl)-piperidine (4-AMP) / CHCl₃ / 0.5 h

12: 1) 15percent NH₃, 2) 0.1 N HCl / 1) 40 h, room temperature, MeOH, 2) DMF

With hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium carbonate; 4-Aminomethylpiperidine; In dichloromethane; chloroform;

DOI:10.1021/jo00289a056

upstream raw materials:

H-Lys(Z)-Phe-Phe-Gly-Leu-Met-OBn

Fmoc-Leu-OH

FMOC-Lys(Z)-Cl

Fmoc-Lys(Z)-OH