C₁₉H₁₄Cl₂N₄O₂

Base Information

• Chemical Name: C₁₉H₁₄Cl₂N₄O₂
• CAS No.: 1131736-89-4
• Molecular Formula: C₁₉H₁₄Cl₂N₄O₂
• Molecular Weight: 401.252
• Mol file: 1131736-89-4.mol

Synonyms:

Chemical Property of C₁₉H₁₄Cl₂N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₄Cl₂N₄O₂

There total 11 articles about C₁₉H₁₄Cl₂N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxyisonicotinic acid (91940-86-2) → C19H14Cl2N4O2 (1131736-89-4)

Guidance literature:

Multi-step reaction with 9 steps

1: oxalyl dichloride / dichloromethane

2: triethylamine / dichloromethane

3: sec.-butyllithium / tetrahydrofuran / -78 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

5: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

6: trichlorophosphate / 100 °C / Microwave irradiation

7: sodium t-butanolate / tetrahydrofuran / 85 °C

8: boron tribromide / chloroform / 85 °C

9: sodium tetrahydroborate / methanol

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sec.-butyllithium; sodium hexamethyldisilazane; boron tribromide; sodium carbonate; triethylamine; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

2-ethoxy-N,N-diisopropylisonicotinamide (1131735-93-7) → C19H14Cl2N4O2 (1131736-89-4)

Guidance literature:

Multi-step reaction with 7 steps

1: sec.-butyllithium / tetrahydrofuran / -78 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

4: trichlorophosphate / 100 °C / Microwave irradiation

5: sodium t-butanolate / tetrahydrofuran / 85 °C

6: boron tribromide / chloroform / 85 °C

7: sodium tetrahydroborate / methanol

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sec.-butyllithium; sodium hexamethyldisilazane; boron tribromide; sodium carbonate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; chloroform;

DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

{4-[(diisopropylamino)carbonyl]-2-ethoxypyridin-3-yl}boronic acid (1131735-94-8) → C19H14Cl2N4O2 (1131736-89-4)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

3: trichlorophosphate / 100 °C / Microwave irradiation

4: sodium t-butanolate / tetrahydrofuran / 85 °C

5: boron tribromide / chloroform / 85 °C

6: sodium tetrahydroborate / methanol

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; boron tribromide; sodium carbonate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; chloroform;

DOI:10.1016/j.bmcl.2014.02.011

upstream raw materials:

2-ethoxyisonicotinic acid

2-ethoxy-N,N-diisopropylisonicotinamide

{4-[(diisopropylamino)carbonyl]-2-ethoxypyridin-3-yl}boronic acid

4'-amino-2-ethoxy-N,N-diisopropyl-3,3'-bipyridine-4-carboxamide